Á¤º¸°úÇÐȸ³í¹®Áö (Journal of KIISE)
Current Result Document :
ÇѱÛÁ¦¸ñ(Korean Title) |
AttDRP: ÁÖÀÇÁýÁß ¸ÞÄ¿´ÏÁò ±â¹ÝÀÇ Ç×¾ÏÁ¦ ¾à¹° ¹ÝÀÀ¼º ¿¹Ãø ¸ðµ¨ |
¿µ¹®Á¦¸ñ(English Title) |
AttDRP: Attention Mechanism-based Model for Anti-Cancer Drug Response Prediction |
ÀúÀÚ(Author) |
ÃÖÁ¾È¯
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Jonghwan Choi
Sangmin Seo
Sanghyun Park
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¿ø¹®¼ö·Ïó(Citation) |
VOL 48 NO. 06 PP. 0713 ~ 0722 (2021. 06) |
Çѱ۳»¿ë (Korean Abstract) |
¾ÏȯÀÚ Áß ÀϺδ Ç×¾ÏÁ¦¿¡ ´ëÇÑ ¾à¹° ÀúÇ×¼ºÀ» º¸¿© ¾à¹°À» ÀÌ¿ëÇÑ Ç×¾ÏÄ¡·á¸¦ ¾î·Æ°Ô ¸¸µç´Ù. ¾à¹° ÀúÇ×¼ºÀº ¾Ï¼¼Æ÷ÀÇ À¯Àüü ÀÌ»ó¿¡ ±âÀÎÇÏ´Â °ÍÀ¸·Î ¹àÇôÁ®, ¾Ï¼¼Æ÷ÁÖ ¹× Ç×¾ÏÁ¦¿¡ ´ëÇÑ ¾à¹° ¹ÝÀÀ¼º µ¥ÀÌÅ͸¦ ºÐ¼®ÇÏ´Â ¿¬±¸°¡ È°¹ßÈ÷ ÀÌ·ç¾îÁö°í ÀÖ´Ù. ±âÁ¸ ¿¬±¸µéÀº ±â°èÇнÀÀ» ÀÌ¿ëÇÏ¿© ¾à¹° ¹Î°¨¼º ¶Ç´Â ÀúÇ×¼ºÀ» ¿¹ÃøÇÏ´Â ¸ðµ¨À» ¿©·µ Á¦¾ÈÇÏ¿´À¸³ª, Ç×¾ÏÁ¦¿Í À¯ÀüÀÚÀÇ °ü°è¸¦ ÇнÀÇÏ´Â ¸ðµ¨ÀÇ ºÎÀç·Î ÀÎÇÏ¿© ¿¹Ãø Á¤È®µµ Çâ»óÀ» À§ÇÑ ¿©Áö°¡ ³²¾ÆÀÖ¾ú´Ù. º» ³í¹®¿¡¼´Â ÁÖÀÇÁýÁß ¸ÞÄ¿´ÏÁòÀ» È°¿ëÇÏ¿© Ç×¾ÏÁ¦ °ü·Ã À¯ÀüÀÚµéÀ» ½Äº°ÇÏ°í, ±×·¯ÇÑ À¯ÀüÀÚµé Á¤º¸¿¡ ±â¹ÝÇÏ¿© Ç×¾ÏÁ¦ ¹ÝÀÀ¼ºÀ» ¿¹ÃøÇÏ´Â AttDRP¸¦ Á¦¾ÈÇÑ´Ù. Á¦¾ÈÇÏ´Â ¸ðµ¨Àº CCLE µ¥ÀÌÅÍ¿¡¼ ±âÁ¸ ¸ðµ¨µéº¸´Ù ³ôÀº ¿¹Ãø Á¤È®µµ¸¦ º¸¿©ÁÖ¾ú°í, AttDRPÀÌ ÇнÀÇÑ ÁÖÀÇÁýÁß ½ºÄھ Ç×¾ÏÁ¦ÀÇ ºÐÀÚ±¸Á¶ ºÐ¼®¿¡ È¿°úÀûÀ¸·Î È°¿ëµÉ ¼ö ÀÖÀ½À» È®ÀÎÇÏ¿´´Ù.
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¿µ¹®³»¿ë (English Abstract) |
Resistance to anti-cancer drugs makes chemotherapy ineffective for cancer patients. Drug resistance is caused by genetic alterations in cancer cells. Many studies have investigated drug responses of diverse cancer cell lines to various anti-cancer drugs to understand drug response mechanisms. Existing studies have proposed machine learning models for drug response prediction to find effective anti-cancer drugs. However, currently there are no models to learn the relationship between anticancer drugs and genes to improve the prediction accuracy. In this paper, we proposed a predictive model AttDRP that could identify important genes associated with anti-cancer drugs and predict drug responses based on identified genes. AttDRP exhibited better predictive accuracy than existing models and we found that the attention scores of AttDRP could be effective tools to analyze molecular structures of anticancer drugs. We hope that our proposed method would contribute to the development of precision medicine for effective chemotherapy. Resistance to anti-cancer drugs makes chemotherapy ineffective for cancer patients. Drug resistance is caused by genetic alterations in cancer cells. Many studies have investigated drug responses of diverse cancer cell lines to various anti-cancer drugs to understand drug response mechanisms. Existing studies have proposed machine learning models for drug response prediction to find effective anti-cancer drugs. However, currently there are no models to learn the relationship between anticancer drugs and genes to improve the prediction accuracy. In this paper, we proposed a predictive model AttDRP that could identify important genes associated with anti-cancer drugs and predict drug responses based on identified genes. AttDRP exhibited better predictive accuracy than existing models and we found that the attention scores of AttDRP could be effective tools to analyze molecular structures of anticancer drugs.
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Å°¿öµå(Keyword) |
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Ç×¾ÏÁ¦
¾à¹°ÀúÇ×¼º
ÁÖÀÇÁýÁß ¸ÞÄ¿´ÏÁò
bioinformatics
precision medicine
anticancer dru
drug resistance
attention mechanism
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